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KMID : 0361120180320010001
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Korean Journal of Transplantation
2018 Volume.32 No. 1 p.1 ~ p.6
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The Role of B Cells in Transplantation Rejection
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Kim Tae-Jin
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Abstract
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B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.
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KEYWORD
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B cell, Transplant rejection, Antibody diversity, Helper T cell, B-1 cell
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